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KMID : 0356720010170030135
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Journal of the Korean Society of Coloproctology
2001 Volume.17 No. 3 p.135 ~ p.140
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Increase of Plasma TGF-β1 Level in Colorectal Cancer Patients
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Lim Chang-Ki
Choi In-Young
Shin Hoon
Ryu Min-Hee
Son Seung-Kook
Jin Seung-Won
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Abstract
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Purpose: Many kinds of malignant tissues, including colorectal cancer were reported to overexpress transforming growth factor-β1 (TGF-β1) gene. However, little work has been done on the circulating TGF-β1 and the association of TGF-β1 with progression in patients with malignant tumors. In this study, we measured the plasma level of TGF-β1 in colorectal cancer patients.
Methods: Enzyme-linked immunosorbent assay (ELISA) was used to measure plasma TGF-β1 level in 52 colorectal cancer patients and 290 normal controls. And carcinoembryonic antigen (CEA) as a tumor marker was compared with TGF-β1 in the aspects of sensitivity and specificity.
Results: The mean plasma TGF-β1 levels were 1.2 19 0.834 (0.272∼5.772) ng/mL in normal control and 8.207 2.428 (1.392∼39.241) ng/mL in colorectal cancer. In comparison with CEA, TGF-β1 is more potent in cancer diagnostic sensitivity.
Conclusion: The results of this study suggest that the plasma TGF-β1 level can be a useful tumor marker in colorectal cancer patients.
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KEYWORD
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CEA, Colorectal cancer, ELISA, TGF-β1, Tumor marker
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